P2RY1
Function
Receptor for extracellular adenine nucleotides such as ADP (PubMed:25822790, PubMed:9038354, PubMed:9442040). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
P2Y purinoceptor 1, P2Y1, ADP receptor, Purinergic receptor, P2RY1