P2RY13
Function
Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
GPR86, GPR94, FKSG77, P2RY13, P2Y purinoceptor 13, P2Y13, G-protein coupled receptor 86, G-protein coupled receptor 94