P2Y4

Function

Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.

Post-translational modifications

Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

Pancreas.

Cellular localization

• Cell membrane
• Multi-pass membrane protein

Alternative names

• P2Y purinoceptor 4
• P2Y4
• P2P
• Uridine nucleotide receptor
• UNR
• NRU
• P2RY4

Database links

• entrezGene:5030
• omim:300038
• swissprot:P51582

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

40963Da