P4HA3
Function
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
Post-translational modifications
N-glycosylation plays no role in the catalytic activity.
Sequence Similarities
Belongs to the P4HA family.
Tissue Specificity
Highly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions.
Cellular localization
- Endoplasmic reticulum lumen
Alternative names
UNQ711/PRO1374, P4HA3, Prolyl 4-hydroxylase subunit alpha-3, 4-PH alpha-3