P4HA3

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.

N-glycosylation plays no role in the catalytic activity.

Belongs to the P4HA family.

Highly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions.

• Endoplasmic reticulum lumen

UNQ711/PRO1374, P4HA3, Prolyl 4-hydroxylase subunit alpha-3, 4-PH alpha-3

• entrezGene:283208
• omim:608987
• swissprot:Q7Z4N8

Proteins

Oncology

61126Da