PA
Function
Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.
Post-translational modifications
Phosphorylated on serines and threonines by host kinases, including human casein kinase II.
Sequence Similarities
Belongs to the influenza viruses PA family.
Cellular localization
- Host cytoplasm
- Host nucleus
- PB1 and PA are transported in the host nucleus as a complex.
Alternative names
Polymerase acidic protein, RNA-directed RNA polymerase subunit P2, PA