PACSIN1
Domain
The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation. In the autoinhibited conformation, interaction with the SH3 domain inhibits membrane tubulation mediated by the F-BAR domain. DNM1 binding abolishes autoinhibition (By similarity).
Function
Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation.
Post-translational modifications
Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).
Sequence Similarities
Belongs to the PACSIN family.
Tissue Specificity
Highly expressed in brain and, at much lower levels, in heart and pancreas.
Cellular localization
- Cytoplasm
- Cell projection
- Synapse
- Synaptosome
- Cell projection
- Ruffle membrane
- Membrane
- Peripheral membrane protein
- Cytoplasmic vesicle membrane
- Peripheral membrane protein
- Synapse
- Cytoplasm
- Cytosol
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain.
Alternative names
KIAA1379, PACSIN1, Protein kinase C and casein kinase substrate in neurons protein 1, Syndapin-1