PAK5
Domain
An autoinhibitory domain is present in the N-terminal region of the protein.
Function
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Post-translational modifications
Autophosphorylated when activated by CDC42/p21.
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Tissue Specificity
Predominantly expressed in brain.
Cellular localization
- Mitochondrion
- Cytoplasm
- Nucleus
- Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.
Alternative names
KIAA1264, PAK7, PAK5, Serine/threonine-protein kinase PAK 5, p21-activated kinase 5, p21-activated kinase 7, PAK-5, PAK-7