PAK6
Function
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
Post-translational modifications
Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Tissue Specificity
Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.
Cellular localization
- Cytoplasm
- Nucleus
- Cotranslocates into nucleus with AR in response to androgen induction.
Alternative names
PAK5, PAK6, Serine/threonine-protein kinase PAK 6, PAK-5, p21-activated kinase 6, PAK-6