PALM
Function
Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner.
Sequence Similarities
Belongs to the paralemmin family.
Tissue Specificity
Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland.
Cellular localization
- Cell membrane
- Lipid-anchor
- Cytoplasmic side
- Cell projection
- Filopodium membrane
- Lipid-anchor
- Cell projection
- Axon
- Cell projection
- Dendrite
- Cell projection
- Dendritic spine
- Basolateral cell membrane
- Lipid-anchor
- Apicolateral cell membrane
- Lipid-anchor
- Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity.
Alternative names
KIAA0270, PALM, Paralemmin-1, Paralemmin