PALM2AKAP2

The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds to and modulates the structure of the actin cytoskeleton.

Isoform 6

Expressed in infantile heart and muscle, and fibroblasts.

• Apical cell membrane
• Lipid-anchor
• GPI-like-anchor
• Cytoplasmic side
• Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons.

KIAA0920, PAKAP, PALM2, PALM2AKAP2, PALM2-AKAP2 fusion protein, A-kinase anchor protein 2, AKAP-KL, Paralemmin A kinase anchor protein, Paralemmin-2, Protein kinase A-anchoring protein 2, AKAP-2, PRKA2

• entrezGene:11217
• omim:604582
• swissprot:Q9Y2D5

Proteins

94661Da