PALM2AKAP2
Domain
The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Function
Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. Binds to and modulates the structure of the actin cytoskeleton.
Tissue Specificity
Isoform 6
Expressed in infantile heart and muscle, and fibroblasts.
Cellular localization
- Apical cell membrane
- Lipid-anchor
- GPI-like-anchor
- Cytoplasmic side
- Accumulates near the inner, apical surface of highly polarized epithelium in tubules of nephrons.
Alternative names
KIAA0920, PAKAP, PALM2, PALM2AKAP2, PALM2-AKAP2 fusion protein, A-kinase anchor protein 2, AKAP-KL, Paralemmin A kinase anchor protein, Paralemmin-2, Protein kinase A-anchoring protein 2, AKAP-2, PRKA2