Pancreatic secretory granule membrane major glycoprotein GP2
Domain
Each ZP domain consists of an N-terminal (ZP-N) and C-terminal (ZP-C) region connected by a flexible linker; the linker allows the ZP domain to wrap around the ZP-C subdomain of the preceding subunit.
Function
Functions as an intestinal M-cell transcytotic receptor specific for type-I-piliated bacteria that participates in the mucosal immune response toward these bacteria. At the apical membrane of M-cells it binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to elicit a mucosal immune response.
Post-translational modifications
N-glycosylated. Glycosylated Asn-65 may be required for interaction with bacterial adhesin fimH.
Tissue Specificity
Expressed in pancreas (at protein level) (PubMed:10760606, PubMed:8666297). Specifically expressed by M (microfold) cells which are atypical epithelial cells of the intestine (at protein level) (PubMed:19907495).
Cellular localization
- Zymogen granule membrane
- Lipid-anchor
- GPI-anchor
- Secreted
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Apical cell membrane
- Lipid-anchor
- GPI-anchor
- Membrane raft
- Lipid-anchor
- GPI-anchor
- Endosome
- Secreted, after cleavage, in the pancreatic juice.
Alternative names
Pancreatic secretory granule membrane major glycoprotein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75, GP2