PANK1

Isoform 1

The N-terminal extension, may be the regulatory domain.

Isoform 1

Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.

Belongs to the type II pantothenate kinase family.

Isoform 1

Expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis.

Isoform 2

Detected at much lower levels in kidney, liver, brain and testis and not detected in heart or skeletal muscle.

• Cytoplasm
• Isoform 1
• Nucleus
• Nucleus
• Nucleolus
• Isoform 2
• Cytoplasm
• Cytosol
• Cytoplasmic vesicle
• Clathrin-coated vesicle
• Recycling endosome

PANK, PANK1, Pantothenate kinase 1, hPanK, hPanK1, Pantothenic acid kinase 1

• entrezGene:53354
• omim:606160
• swissprot:Q8TE04

Proteins

64339Da