Pantetheinase
Function
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.
Sequence Similarities
Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
Tissue Specificity
Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
Pantetheinase, Pantetheine hydrolase, Tiff66, Vascular non-inflammatory molecule 1, Vanin-1, VNN1