Pannexin 1

Ion channel involved in a variety of physiological functions such as blood pressure regulation, apoptotic cell clearance and oogenesis (PubMed:15304325, PubMed:16908669, PubMed:20829356, PubMed:20944749, PubMed:30918116). Forms anion-selective channels with relatively low conductance and an order of permeabilities: nitrate>iodide>chlroride>>aspartate=glutamate=gluconate (By similarity). Can release ATP upon activation through phosphorylation or cleavage at C-terminus (PubMed:32238926). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669).

Caspase-activated pannexin-1

During apoptosis, the C terminal tail is cleaved by caspases, which opens the main pore acting as a large-pore ATP efflux channel with a broad distribution, which allows the regulated release of molecules and ions smaller than 1 kDa, such as nucleotides ATP and UTP, and selective plasma membrane permeability to attract phagocytes that engulf the dying cells.

Oocyte/zygote/embryo maturation arrest 7

OZEMA7

An autosomal dominant infertility disorder due to oocyte degeneration and death, which may occur before or after fertilization.

None

The disease is caused by variants affecting the gene represented in this entry.

S-nitrosylation inhibits channel currents and ATP release.

N-glycosylation plays a role in cell surface targeting. Glycosylation at its extracellular surface makes unlikely that two oligomers could dock to form an intercellular channel such as in gap junctions (PubMed:17715132, PubMed:32494015, PubMed:33947837). Exists in three glycosylation states: non-glycosylated (GLY0), high-mannose glycosylated (GLY1), and fully mature glycosylated (GLY2) (PubMed:30918116).

Cleaved by CASP3 and CASP7 during apoptosis. Cleavage opens the channel for the release of metabolites and induces plasma membrane permeability during apoptosis.

Phosphorylated at Tyr-199 by SRC. Phosphorylation activates ATP release. Constitutively phosphorylated in vascular smooth muscle cells.

Belongs to the pannexin family.

Widely expressed (PubMed:30918116). Highest expression is observed in oocytes and brain (PubMed:30918116). Detected at very low levels in sperm cells (PubMed:30918116).

• Cell membrane
• Multi-pass membrane protein
• Endoplasmic reticulum membrane
• Multi-pass membrane protein

MRS1, UNQ2529/PRO6028, PANX1, Pannexin-1

• entrezGene:24145
• omim:608420
• swissprot:Q96RD7

Proteins

Neuroscience

48050Da