PAOX
Function
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380).
Pathway
Amine and polyamine metabolism; spermine metabolism.
Sequence Similarities
Belongs to the flavin monoamine oxidase family.
Tissue Specificity
Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.
Cellular localization
- Peroxisome
- Cytoplasm
Alternative names
PAO, UNQ1923/PRO4398, PAOX, Peroxisomal N(1)-acetyl-spermine/spermidine oxidase, Polyamine oxidase