PAQR8
Function
Plasma membrane progesterone (P4) receptor coupled to G proteins (PubMed:23763432). Seems to act through a G(i) mediated pathway (PubMed:23763432). May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (PubMed:23161870).
Sequence Similarities
Belongs to the ADIPOR family.
Tissue Specificity
Highly expressed in the hypothalamus (PubMed:23161870). Also expressed in spinal cord, kidney and testis.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Colocalizes with a lysosomal protein CTSD/cathepsin D.
Alternative names
C6orf33, LMPB1, MPRB, PAQR8, Membrane progestin receptor beta, mPR beta, Lysosomal membrane protein in brain 1, Membrane progesterone P4 receptor beta, Membrane progesterone receptor beta, Progesterone and adipoQ receptor family member 8, Progestin and adipoQ receptor family member 8, Progestin and adipoQ receptor family member VIII