Parathyroid hormone
GeneName
PTH
Summary
Parathyroid hormone (PTH), also known as hPTH or parathyrin, is a 13 kDa peptide hormone secreted by the parathyroid glands. It plays a vital role in calcium and phosphate homeostasis, primarily by regulating bone mineralization and resorption. PTH exerts its effects by binding to the type 1 parathyroid hormone receptor, activating G protein-coupled receptor signalling pathways that lead to increased intracellular cAMP levels. It is expressed in the extracellular region and is involved in various biological processes, including cell-cell signalling and the regulation of gene expression related to bone metabolism.
Importance
PTH is relevant to: - Bone health and metabolic bone diseases, such as osteoporosis, through its regulation of bone turnover and mineral homeostasis - Disorders of calcium metabolism, including hyperparathyroidism and hypoparathyroidism, which can lead to significant clinical consequences - The interplay between calcium and vitamin D in maintaining mineral balance and skeletal integrity - Potential therapeutic targets for bone-related conditions and strategies for enhancing bone regeneration and repair
Top Products
For researchers investigating PTH, we recommend two primary antibodies that cater to different experimental needs. The first is the well-regarded monoclonal antibody, Anti-Parathyroid Hormone antibody [A1/70] (ab14493), which is particularly suited for ELISA applications. While it has not yet accumulated citations, it is a trusted choice for those focusing on this specific assay. Additionally, we offer the recombinant antibody, Anti-Parathyroid Hormone antibody [EPR8480] (ab166631), which has been validated for use in immunohistochemistry (IHC) and western blotting (WB). This antibody has garnered 2 citations, indicating its growing acceptance in the research community. The recombinant nature of this product ensures batch-to-batch consistency, making it an excellent option for researchers seeking reliable results in their studies of PTH. The Anti-Parathyroid Hormone antibody [PTH/911] - N-terminal ELISA Kit (ab216041) is an excellent option for researchers looking to study PTH in their experiments.
Abcam Product Citation Summary
The data indicates that PTH antibodies are being utilised in research related to rheumatoid arthritis in humans, highlighting the potential role of PTH in this condition.
Abcam Product Citation Table
Function
Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion (PubMed:11604398, PubMed:35932760). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed:18375760, PubMed:35932760). Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (PubMed:21076856).
Involvement in disease
Hypoparathyroidism, familial isolated, 1
FIH1
A form of hypoparathyroidism, a disorder characterized by hypocalcemia and hyperphosphatemia due to a deficiency of parathyroid hormone. Clinical features include seizures, tetany and cramps. FIH1 inheritance can be autosomal dominant or recessive.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the parathyroid hormone family.
Cellular localization
- Secreted
Alternative names
Parathyroid hormone, PTH, Parathormone, Parathyrin