PARD3B
Domain
The N-terminal part (1-351) part blocks the association of the tight junction marker TJP1 with the cell-cell boundary when it is overexpressed.
Function
Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions.
Sequence Similarities
Belongs to the PAR3 family.
Tissue Specificity
Highly expressed in kidney, lung and skeletal muscle. Expressed at intermediate levels in brain, heart, placenta, liver and pancreas. Isoform 1 is predominant, while isoform 2 and isoform 3 are expressed at lower levels.
Cellular localization
- Endomembrane system
- Cell junction
- Cell junction
- Tight junction
- Partially localized along the cell-cell contact region. Colocalizes with TJP1 to epithelial tight junctions.
Alternative names
ALS2CR19, PAR3B, PAR3L, PARD3B, Partitioning defective 3 homolog B, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein, PAR3-beta, Partitioning defective 3-like protein, PAR3-L protein