The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
The PDZ domain mediates interaction with PALS1.
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Belongs to the PAR6 family.
Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.
PAR6B, PARD6B, Partitioning defective 6 homolog beta, PAR-6 beta, PAR-6B
Proteins
Developmental Biology
41182Da
We found 2 products in 2 categories
ab234786