PARD6B
Domain
The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
The PDZ domain mediates interaction with PALS1.
Function
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
Sequence Similarities
Belongs to the PAR6 family.
Tissue Specificity
Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.
Cellular localization
- Cytoplasm
- Cell membrane
- Cell junction
- Tight junction
Alternative names
PAR6B, PARD6B, Partitioning defective 6 homolog beta, PAR-6 beta, PAR-6B