PARP4
Function
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.
Sequence Similarities
Belongs to the ARTD/PARP family.
Tissue Specificity
Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.
Cellular localization
- Cytoplasm
- Nucleus
- Cytoplasm
- Cytoskeleton
- Spindle
- Also found in the nucleus, associated with mitotic spindles.
Alternative names
ADPRTL1, KIAA0177, PARPL, PARP4, Protein mono-ADP-ribosyltransferase PARP4, 193 kDa vault protein, ADP-ribosyltransferase diphtheria toxin-like 4, PARP-related/IalphaI-related H5/proline-rich, Poly [ADP-ribose] polymerase 4, Vault poly(ADP-ribose) polymerase, ARTD4, PH5P, PARP-4, VPARP