PATL1
Domain
The region A, also named N-term, mediates the interaction with DDX6/RCK and is required for cytoplasmic mRNA processing body assembly.
The region C, also named Pat-C, is required for RNA-binding and mediates the binding with the Lsm-containing SMN-Sm protein complex and the decapping machinery. It folds into an alpha-alpha superhelix, exposing conserved and basic residues on one side of the domain.
Function
RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261).
(Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV).
Sequence Similarities
Belongs to the PAT1 family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- P-body
- Nucleus
- Nucleus
- PML body
- Nucleus speckle
- Predominantly cytoplasmic (PubMed:22090346). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:22090346). Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus (PubMed:22090346).
Alternative names
OK/KNS-cl.5, PATL1, Protein PAT1 homolog 1, PAT1-like protein 1, Protein PAT1 homolog b, Pat1b, hPat1b