Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.
Phosphorylated; in a cell-cycle dependent manner at mitosis.
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.
TOPK, PBK, Lymphokine-activated killer T-cell-originated protein kinase, Cancer/testis antigen 84, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, Spermatogenesis-related protein kinase, T-LAK cell-originated protein kinase, CT84, SPK
Proteins
Immunology & Infectious Disease
36085Da
We found 15 products in 3 categories
ab226923
ab244888
Anti-PDZ Binding Kinase antibody [EPR2520-35] - BSA and Azide free (Detector)
ab244628
Anti-PDZ Binding Kinase antibody [EPR2519-3] - BSA and Azide free (Capture)