PBK

Function

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.

Post-translational modifications

Phosphorylated; in a cell-cycle dependent manner at mitosis.

Sequence similarities

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

Tissue specificity

Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules.

Alternative names

• Lymphokine-activated killer T-cell-originated protein kinase
• Cancer/testis antigen 84
• MAPKK-like protein kinase
• Nori-3
• PDZ-binding kinase
• Spermatogenesis-related protein kinase
• T-LAK cell-originated protein kinase
• CT84
• SPK
• TOPK
• PBK

Database links

• entrezGene:55872
• omim:611210
• swissprot:Q96KB5

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

36085Da