pbpA
Function
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Sequence Similarities
In the N-terminal section; belongs to the glycosyltransferase 51 family.
In the C-terminal section; belongs to the transpeptidase family.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
Alternative names
CBO3083, CLC_2985, pbpA, Penicillin-binding protein 1A, PBP1a