pbpC
Developmental stage
Present in all growth stages and in both inner and outer forespore membranes.
Function
Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis (Probable). Probably required for both cortical and vegetative peptidoglycan synthesis (Probable). Although not usually required for cell division, in the absence of PBP 2B (pbpB) it becomes essential. Confers resistance to oxacillin and cephalexin (PubMed:28792086).
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Sequence Similarities
Belongs to the transpeptidase family.
Cellular localization
- Cell membrane
- Single-pass membrane protein
- Forespore inner membrane
- Single-pass membrane protein
- Forespore outer membrane
- Single-pass membrane protein
- Membrane raft
- Single-pass membrane protein
- Localizes at mid cell; localization requires FtsZ and PBP 2B (pbpB) (PubMed:28792086). Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion (PubMed:20713508, PubMed:22882210).
Alternative names
ycsM, yzsA, BSU04140, pbpC, Penicillin-binding protein 3, PBP 3, PSPB20, Penicillin-binding protein C