pbpX
Function
A transpeptidase that forms peptide cross-links between adjacent glycan strands in cell wall peptidoglycan (PG). Part of the divisome machinery that synthesizes the septal cross wall. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.
Sequence Similarities
Belongs to the transpeptidase family.
Cellular localization
- Cell membrane
- Single-pass membrane protein
Alternative names
spr0304, pbpX, Penicillin-binding protein 2X, PBP-2X, PBP2X