PC
Function
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Pathway
Carbohydrate biosynthesis; gluconeogenesis.
Post-translational modifications
Acetylation of Lys-748 might play a role in catalytic activity regulation.
Cellular localization
- Mitochondrion matrix
Alternative names
Pyruvic carboxylase, PCB