PCF11
Function
Component of pre-mRNA cleavage complex II, which promotes transcription termination by RNA polymerase II.
Post-translational modifications
Phosphorylation at Ser-120 and/or Thr-121 by WNK1 weakens its association with POLR2A/RNA polymerase II, promoting transcript release from the chromatin template and mRNA export to the cytoplasm.
Cellular localization
- Nucleus
Alternative names
KIAA0824, PCF11, Pre-mRNA cleavage complex 2 protein Pcf11, Pre-mRNA cleavage complex II protein Pcf11