Pcgf6
Developmental stage
Expressed in embryo at 10.5 dpc.
Function
Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
Post-translational modifications
Phosphorylated during mitosis.
Tissue Specificity
Expressed in ovary, testis, stomach, liver, thymus and kidney (at protein level).
Cellular localization
- Nucleus
Alternative names
Mblr, Rnf134, Pcgf6, Polycomb group RING finger protein 6, Mel18 and Bmi1-like RING finger, RING finger protein 134