Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
Proprotein convertase 1 deficiency
PC1 deficiency
Characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction It is due to impaired processing of prohormones.
None
The disease is caused by variants affecting the gene represented in this entry.
O-glycosylated.
Belongs to the peptidase S8 family. Furin subfamily.
NEC1, PCSK1, Neuroendocrine convertase 1, NEC 1, Prohormone convertase 1, Proprotein convertase 1, PC1
Proteins
Immunology & Infectious Disease
84152Da
We found 3 products in 1 category
ab191452