Pcsk1
Function
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
Sequence Similarities
Belongs to the peptidase S8 family. Furin subfamily.
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle
- Localized in the secretion granules.
Alternative names
Att-1, Nec-1, Nec1, Pcsk1, Neuroendocrine convertase 1, NEC 1, Furin homolog, PC3, Prohormone convertase 1, Propeptide-processing protease, Proprotein convertase 1, PC1