PCSK2
Function
Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells.
Sequence Similarities
Belongs to the peptidase S8 family. Furin subfamily.
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle
- Secreted
- Localized in the secretion granules.
Alternative names
NEC2, PCSK2, Neuroendocrine convertase 2, NEC 2, KEX2-like endoprotease 2, Prohormone convertase 2, Proprotein convertase 2, PC2