PCYOX1
Function
Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (PubMed:10585463, PubMed:11078725, PubMed:12186880). Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides (By similarity). Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded (PubMed:10585463).
Sequence Similarities
Belongs to the prenylcysteine oxidase family.
Tissue Specificity
Widely expressed.
Cellular localization
- Lysosome
Alternative names
KIAA0908, PCL1, UNQ597/PRO1183, PCYOX1, Prenylcysteine oxidase 1, Prenylcysteine lyase