PCYT1B
Function
Isoform 1
Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
Isoform 2
Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
Pathway
Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.
Post-translational modifications
Isoform 1
Phosphorylated.
Isoform 2
Extensively phosphorylated.
Sequence Similarities
Belongs to the cytidylyltransferase family.
Tissue Specificity
Isoform 1
Highly expressed in testis, placenta, brain, ovary, liver and fetal lung.
Isoform 2
Expressed in brain, liver and fetal lung.
Cellular localization
- Isoform 1
- Cytoplasm
- Endoplasmic reticulum
- Isoform 2
- Endoplasmic reticulum
Alternative names
CCTB, PCYT1B, Choline-phosphate cytidylyltransferase B, CCT-beta, CTP:phosphocholine cytidylyltransferase B, Phosphorylcholine transferase B, CCT B, CT B