PDCD1LG2

Function

Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity).

Sequence Similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Tissue Specificity

Highly expressed in heart, placenta, pancreas, lung and liver and weakly expressed in spleen, lymph nodes and thymus.

Cellular localization

• Isoform 3
• Secreted
• Isoform 2
• Endomembrane system
• Single-pass type I membrane protein
• Isoform 1
• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD273, B7DC, PDCD1L2, PDL2, PDCD1LG2, Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC

Database links

swissprot:Q9BQ51 entrezGene:80380 omim:605723

Other research areas

• Immunology & Infectious Disease