Pdcd1lg2

Function

Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Sequence Similarities

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Tissue Specificity

Expressed in immature and mature bone marrow-derived dendritic cells and splenic dendritic cells. Highly expressed in placenta, liver and weakly expressed in heart, spleen, lymph nodes and thymus. Also expressed in some tumor cell lines of lymphoid origin.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD273, B7dc, Btdc, Cd273, Pdl2, Pdcd1lg2, Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC

Database links

swissprot:Q9WUL5 entrezGene:58205

Other research areas

• Immunology & Infectious Disease