PDCL
Function
Acts as a positive regulator of hedgehog signaling and regulates ciliary function.
Isoform 1
Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.
Isoform 2
Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.
Sequence Similarities
Belongs to the phosducin family.
Cellular localization
- Cell projection
- Cilium
Alternative names
PHLOP1, PhLP1, PDCL, Phosducin-like protein, PHLP