The tandem GAF domains bind cGMP, and regulate enzyme activity. The binding of cGMP stimulates enzyme activity.
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:15800654). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (By similarity).
Belongs to the cyclic nucleotide phosphodiesterase family.
Expressed in testis and developing spermatoza.
cAMP and cGMP phosphodiesterase 11A, Pde11a
Proteins
Immunology & Infectious Disease
104563Da
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