PDE2A

Domain

The GAF 1 domain functions as a dimerization domain.

The GAF 2 domains binds cGMP, which acts as an allosteric activator.

Function

cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:21724846). Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity).

Isoform PDE2A2

Regulates mitochondrial cAMP levels and respiration (PubMed:21724846). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107).

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.

Tissue specificity

Isoform PDE2A2

Expressed in brain and liver (at protein level).

Cellular localization

• Isoform PDE2A1
• Cytoplasm
• Isoform PDE2A2
• Mitochondrion matrix
• Mitochondrion inner membrane
• Mitochondrion outer membrane
• Isoform PDE2A3
• Cell membrane
• Lipid-anchor

Alternative names

• Cyclic GMP-stimulated phosphodiesterase
• CGS-PDE
• cGSPDE
• Pde2a

Database links

• entrezGene:207728
• swissprot:Q922S4

Target type

Proteins

Molecular weight

105619Da