Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:10454575). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (By similarity). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (PubMed:15294162).
Phosphorylation at Ser-273 mediates insulin-induced activation of PDE3B.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
Abundant in adipose tissues.
CGIPDE1, Cyclic GMP-inhibited phosphodiesterase B, CGI-PDE B, Pde3b
Proteins
Immunology & Infectious Disease
122154Da
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ab95814