Pde3b
Function
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:10454575). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (By similarity). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (PubMed:15294162).
Post-translational modifications
Phosphorylation at Ser-273 mediates insulin-induced activation of PDE3B.
Sequence Similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.
Tissue Specificity
Abundant in adipose tissues.
Cellular localization
- Membrane
- Multi-pass membrane protein
Alternative names
CGIPDE1, Cyclic GMP-inhibited phosphodiesterase B, CGI-PDE B, Pde3b