Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes.
Isoform 1
Efficiently hydrolyzes cAMP.
Isoform 2
Efficiently hydrolyzes cAMP.
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Isoform 1
Phosphorylated by MAPKAPK2 at Ser-147; it counteracts PKA-induced activation of PDE4A and modulates intracellular cAMP levels. Likely involved in cellular desensitization to cAMP signaling.
Proteolytically cleaved by CASP3.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Isoform 2
Isoform 2 is testis specific.
DPDE2, cAMP-specific phosphodiesterase 4A, Pde4a
Proteins
Immunology & Infectious Disease
93439Da
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