Pde4a
Function
Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes.
Isoform 1
Efficiently hydrolyzes cAMP.
Isoform 2
Efficiently hydrolyzes cAMP.
Pathway
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Post-translational modifications
Isoform 1
Phosphorylated by MAPKAPK2 at Ser-147; it counteracts PKA-induced activation of PDE4A and modulates intracellular cAMP levels. Likely involved in cellular desensitization to cAMP signaling.
Proteolytically cleaved by CASP3.
Sequence Similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Tissue Specificity
Isoform 2
Isoform 2 is testis specific.
Cellular localization
- Isoform 2
- Cytoplasm
- Cytosol
- Membrane
- Peripheral membrane protein
Alternative names
DPDE2, cAMP-specific phosphodiesterase 4A, Pde4a