PDE4B3

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.

Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.

Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.

Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015).

Isoform PDE4B5

Brain-specific isoform.

• Isoform PDE4B5
• Cytoplasm
• Cell membrane

DPDE4, PDE4B, PDE32, cAMP-specific phosphodiesterase 4B

• entrezGene:5142
• omim:600127
• swissprot:Q07343

Proteins

Immunology & Infectious Disease

83343Da