Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Expressed in brain, heart, lung and skeletal muscle.
Proteins
Cardiovascular
83343Da
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