PDE4DIP
Domain
Isoform 13
Residues 1-150 are involved in AKAP9-binding.
Function
Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity).
Isoform 13
Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PubMed:25217626, PubMed:27666745, PubMed:28814570, PubMed:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PubMed:29162697).
Involvement in disease
A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein.
Tissue Specificity
Highly expressed in adult and fetal heart, in skeletal muscle and, to a lower extent, in brain and placenta.
Cellular localization
- Golgi apparatus
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Isoform 13
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Cytoplasm
- Cytoskeleton
- Golgi apparatus
- Associated with the microtubule network at the growing distal tip of microtubules (PubMed:29162697). Targeting to the Golgi apparatus requires AKAP9 (PubMed:25217626).
Alternative names
CMYA2, KIAA0454, KIAA0477, MMGL, PDE4DIP, Myomegalin, Cardiomyopathy-associated protein 2, Phosphodiesterase 4D-interacting protein