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PDE6 alpha

Function

This protein participates in processes of transmission and amplification of the visual signal.

Involvement in disease

Retinitis pigmentosa 43

RP43

A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Cellular localization

  • Cell membrane
  • Lipid-anchor
  • Cytoplasmic side

Alternative names

  • GMP-PDE alpha
  • PDE V-B1
  • PDEA
  • PDE6A

Target type

Proteins

Molecular weight

99547Da