Pde6d
Function
Promotes the release of prenylated target proteins from cellular membranes (PubMed:22179043). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22179043). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (PubMed:22179043). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.
Sequence Similarities
Belongs to the PDE6D/unc-119 family.
Cellular localization
- Cytoplasm
- Cytosol
- Cytoplasmic vesicle membrane
- Peripheral membrane protein
- Cytoplasm
- Cytoskeleton
- Cilium basal body
Alternative names
GMP-PDE delta, Pde6d