PDE6D

Promotes the release of prenylated target proteins from cellular membranes (PubMed:22179043). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22179043). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (PubMed:22179043). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.

Belongs to the PDE6D/unc-119 family.

• Cytoplasm
• Cytosol
• Cytoplasmic vesicle membrane
• Peripheral membrane protein
• Cytoplasm
• Cytoskeleton
• Cilium basal body

GMP-PDE delta, Pde6d

• swissprot:O55057

Proteins

Immunology & Infectious Disease

17348Da