PDE7A
Developmental stage
Isoform PDE7A1
Developmentally regulated (PubMed:9195912). PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development (PubMed:9195912). It persists strongly only in adult skeletal muscle (PubMed:9195912).
Isoform PDE7A2
Developmentally regulated (PubMed:9195912). PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development (PubMed:9195912). It persists strongly only in adult skeletal muscle (PubMed:9195912).
Domain
Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912).
Pathway
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
Sequence Similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
Tissue Specificity
Isoform PDE7A1
Found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart (PubMed:9195912). It is expressed as well in two T-cell lines (PubMed:9195912).
Isoform PDE7A2
Found abundantly in skeletal muscle and at low levels in heart.
Cellular localization
- Isoform PDE7A1
- Cytoplasm
- Cytosol
- PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.
- Isoform PDE7A2
- Cytoplasm
- PDE7A2 (50 kDa) is located to particulate cellular fractions.
Alternative names
HCP1, TM22, cAMP-specific phosphodiesterase 7A, PDE7A