PDE9A

Function

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:18757755, PubMed:21483814, PubMed:9624146). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).

Pathway

Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.

Sequence Similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.

Tissue Specificity

Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood (PubMed:9624146). Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate (PubMed:12565835). In brain, present in the cortex, cerebellum, and subiculum (at protein level) (PubMed:22328573). In heart, primarily localizes to myocytes (PubMed:25799991).

Cellular localization

• Isoform PDE9A1
• Cell projection
• Ruffle membrane
• Cytoplasm
• Perinuclear region
• Golgi apparatus
• Endoplasmic reticulum
• Cell membrane
• Sarcolemma
• Isoform PDE9A2
• Cell projection
• Ruffle membrane
• Cytoplasm
• Perinuclear region
• Isoform PDE9A3
• Cytoplasm
• Endoplasmic reticulum
• Isoform PDE9A17
• Cytoplasm
• Endoplasmic reticulum

Alternative names

PDE9A

Database links

swissprot:O76083 swissprot:O76083-2 genbank:NP_001001567.1 omim:602973 entrezGene:5152