PDGFA

Domain

The long form contains a basic insert which acts as a cell retention signal.

Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity).

Sequence Similarities

Belongs to the PDGF/VEGF growth factor family.

Cellular localization

• Secreted
• Released by platelets upon wounding.

Alternative names

PDGF1, PDGFA, Platelet-derived growth factor subunit A, PDGF subunit A, PDGF-1, Platelet-derived growth factor A chain, Platelet-derived growth factor alpha polypeptide

Database links

swissprot:P04085 entrezGene:5155 entrezGene:5154 swissprot:P01127 omim:190040 omim:173430