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PDGF B
Function
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).
Involvement in disease
Basal ganglia calcification, idiopathic, 5
IBGC5
A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.
None
The disease is caused by variants affecting the gene represented in this entry.
A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.
Sequence similarities
Belongs to the PDGF/VEGF growth factor family.
Tissue specificity
Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.
Cellular localization
- Secreted
- Released by platelets upon wounding.
Alternative names
- Platelet-derived growth factor subunit B
- PDGF subunit B
- PDGF-2
- Platelet-derived growth factor B chain
- Platelet-derived growth factor beta polypeptide
- Proto-oncogene c-Sis
- PDGFB
- SIS
- PDGF2
Target type
Proteins
Primary research area
Immuno-oncology
Other research areas
- Oncology
Molecular weight
27283Da