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PDIA2/PDIP

Function

Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.

Post-translational modifications

The disulfide-linked homodimer exhibits an enhanced chaperone activity.

Glycosylated.

Sequence similarities

Belongs to the protein disulfide isomerase family.

Tissue specificity

Highly expressed in pancreas (at protein level).

Cellular localization

  • Endoplasmic reticulum lumen

Alternative names

  • Protein disulfide-isomerase A2
  • Pancreas-specific protein disulfide isomerase
  • PDIp
  • PDIA2
  • PDIP

Target type

Proteins

Molecular weight

58206Da