PDIA6

May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).

Belongs to the protein disulfide isomerase family.

Expressed in platelets (at protein level).

• Endoplasmic reticulum lumen
• Cell membrane
• Melanosome
• Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).

ERP5, P5, TXNDC7, PDIA6, Protein disulfide-isomerase A6, Endoplasmic reticulum protein 5, Protein disulfide isomerase P5, Thioredoxin domain-containing protein 7, ER protein 5, ERp5

• entrezGene:10130
• omim:611099
• swissprot:Q15084

Proteins

Immunology & Infectious Disease

48121Da